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Keywords: endocytosis, arrestin, ubiquitin, phosphorylation, recycling Desensitization: a protective measure to block overstimulation G protein-coupled receptors (GPCRs) transduce signals originating from the extracellular space to the biochemical and genetic machinery inside a cell and lead to responses including vision, olfaction, taste, vascular tone, muscle contraction, pain and behavior

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